Nalloxan induced diabetes in rats pdf free download

Glycemic effect of honey on alloxan induced diabetes and with concomitant administration of fructose was studied in male rats of the wistar strain. Others found a significant difference in alloxan plasma levels in children with and without diabetes type 1. Szkudelski department of animal physiology and biochemistry, university of agriculture, poznan, poland received november 2, 2000 accepted march 20, 2001 summary alloxan and streptozotocin are widely used to induce experimental diabetes in animals. Protective role of phyllanthus fraternus in alloxan induced diabetes in rat s, j ayurveda integr med. Effects of methanol extract of chrysophyllum albidum seeds. Effect of silymarin on the concentration of plasma glucose during the development of alloxan induced diabetes mellitus. Male wister rats were used, and randomly divided into five groups 68. Alloxan induced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. Hyperglycaemic rats were treated with or without oral hypoglycaemic drugs metformin, 150 mgkgd. It was found that diabetes was induced in about 24 hours. In addition, it was reported that very high lipid levels can be induced in obese zucker diabetic fatty zdf rats, using high saturated fat and.

Article information, pdf download for amelioration of streptozotocininduced diabetic nephropathy by. Induction of diabetes by streptozotocin in rats ncbi nih. The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. Reduction of blood glucose level was significantly higher after the administration of ir than mr formulation. This raises the question of safety and possible toxicity. The responses are accompanied by corresponding inverse changes in plasma insulin and sequential ultrastructural. For induction of experimental diabetes in male adult rats weighted 250300 grams 7590 days. Pharmacokinetics and pharmacodynamics of gliclazide from.

A closed fracture was performed on the left tibia of 3monthold wistar rats weighing 250 to 350 g that were either healthy n 24 or made diabetic with alloxan n 24 to investigate the effect of alloxan induced diabetes on the course of bone fracture healing. After 24 hours, the blood samples analysed for blood glucose level. The objective of the study was to ascertain the safety and possible metabolic toxicity in comparison with metformin, a known drug associated with acidosis. Effect of shilajit on blood glucose and lipid profile in. Since carbohydrate metabolism is modified in diabetic animals, its of interest to determine the effect of tryptophan on alloxan induced diabetic rat. Moringa oleifera mo is used for a number of therapeutic purposes. Alloxan definition of alloxan by medical dictionary. In diabetes mellitus the body cannot secrete enough insulin or it cannot use its. In the present study, we report the effects of induced diabetes and its treatment with or without oral hypoglycaemic drugs on the morphology and oxidative stress status of the prefrontal cortex. Pdf antidiabetic and hypolipidemic effect of asparagus. Alloxaninduced diabetes triggers the development of.

The extracts of the leaves was tested for its efficacy in alloxan induced diabetic rats. Mainly two chemicals are use in inducing diabetes, they are. Highfructose and highfat dietinduced disorders in rats. A total of 35 male wistar rats were divided into 5 groups as follows. Treatment of diabetic rats with sodium phthalhydrazide partially reversed diabetogenic pathology in the alloxan induced diabetes. Nephroprotective effect of stevioside in diabetic rats.

Hyperglycaemia was induced in fasted wistar rats with alloxan 150 mgkg body weight. Comparison of streptozotocin and alloxaninduced diabetes in. Periodontal disease in diabetic patients presents higher severity and prevalence. The clinical course of the diabetes mortality, hyperglycemia, weight loss, polydipsia, hyperphagia, polyuria, glycosuria and diabetic indices was recorded for six weeks before the animals were sacrificed for volumetric quantitation of the pancreatic islets. Antihyperglycemic and antihyperlipidaemic effect of polygala. The full text of this article is available as a pdf 180k. Short and longterm glycemic control of streptozotocininduced. Animals confirmed with diabetes were grouped into 2 groups. The best known druginduced diabetes model is the alloxan diabetes. The highest pharmacodynamic efficacy of gliclazide was observed in the normal animals group after administration of the ir tablets, while hypoglycemic effect of the drug was diminished in animals with induced diabetes.

Hypoglycaemic activity of ethanolic extract of garcinia mangostana. The rats were administered with 150mgkg of alloxan intraperitonially. Pdf hypoglycemic and antihyperlipidemic effects of. Diabetes mellitus is the most important non infective epidemic to. Diabetes was induced in rats with equal molar dosages of either streptozotocin or alloxan. Thirty nondiabetic control rats nc and 30 untreated diabetic ud rats were divided into three subgroups sacrificed after 6, 14, or 26 weeks.

Alloxaninduced diabetes and bone repair 373 issn 0100879x. Research article alloxan induced diabetes mellitus in. Hypoglycemic and antihyperlipidemic effects of adiantum caudatum in alloxan induced diabetes in rats article pdf available in asian journal of pharmaceutical and clinical research 91. Intravenous injection of 60mgkg dose of streptozotocin in adult wistar rats, makes pancreas swell and at last. The onset of t2dm is preceded by an expressive increase in the plasma levels of free fatty acids ffa and by sixfold rise in triglyceride tg. The extracts of gossypium herbaceum administered daily. Open access treatment of alloxaninduced diabetic rats with. Antidiabetic activity of gossypium herbaceum by alloxan. Experimental diabetes induced by alloxan and streptozotocin. Effect of combined dyslipidemia and hyperglycemia on diabetic. Effect of shilajit on blood glucose and lipid profile in alloxan induced diabetic rats n. Therefore, mice should be protected in specific pathogenfree spf conditions to. Previously it has been reported that up780, a standardized composition of aloe chromone formulated with an aloe polysaccharide, has a significant impact in reducing hba1c, fasting blood glucose, fructosamine and plasma insulin level in humans and improved impaired glucose and insulin.

Pdf protective role of phyllanthus fraternus in alloxan. The levels of glucokinase, phosphofructokinase pfk and pyruvate kinase pk in the liver are decreased in alloxan diabetes and starvation, and are increased on refeeding. Experimental diabetes mellitus in different animal models hindawi. The proximate composition of chrysophyllum albidum seed methanol extract was found to contain crude protein 8. Partial recovery from alloxaninduced diabetes by sodium. Histophysiology of the obesity diabetes syndrome in sand rats top results of your surfing histophysiology of the obesity diabetes syndrome in sand rats start download portable document format pdf and ebooks electronic books free online rating news 20162017 is books that can provide inspiration, insight, knowledge to the reader. Alloxaninduced diabetes, a common model for evaluating. Effect of alloxan diabetes, starvation and refeeding on.

To study the effect of shilajit a herbomineral preparation on blood glucose and lipid profile in euglycemic and alloxan induced diabetic rats and its effects on the above parameters in. Treatment of alloxaninduced diabetic rats with metformin or. Blood glucose lowering activity of aloe based composition. Sivakumari hind institute of science and technology ficus racemosa is a medium tall tree with quite rich green foliage that provides good shade. Passiflora edulis, antidiabetic, hyperglycemia, alloxan mono hydrate introduction nsulin is the principal hormone secreted by. Zucker diabetic fatty rats for research in diabetes intechopen.

It has been successfully induced in a variety of animal species. All the rats were fasted for 16 h prior to treatment, but allowed a free access to water. This study evaluated the longterm effects of alloxan induced diabetes in rat liver. Anti diabetic effects officus racemosa on lipid profile in alloxan induced diabetic rats v. Antidiabetic and hypolipidemic effect of asparagus racemosus in alloxan induced diabetes in rats.

The animals were deprived of food for 48 hours, and then weighed and anaesthesized with chloroform in a glass dome. Effects of alloxan diabetes and adrenaline on concentrations of free fatty acids in rat heart and diaphragm muscles. Stz and alloxan induced diabetic mice scientist solutions. Evaluation of gme effect on stzinduced diabetic rats. Thus, the present results not only affirmed the diabetes ameliorating effects of diabecon in adolescent male rats but also supported the role of antioxidants in its mechanism of action. Differential effect of honey on selected variables in alloxan. Alloxaninduced diabetes mellitus how is alloxaninduced. Prevention of alloxaninduced diabetes mellitus in the rat. Studies suggests that alloxan does not cause diabetes in humans. Diabetes was induced in groups 19 consisting of rats aged 3, 5, 7, 9, 11, 15, 17 and 19 weeks respectively by injecting 160 mgkg of alloxan monohydrate intraperitoneally while group 10 rats. Anti hyperglycemic, anti oxidant, anti hyperlipidemic. Antidiabetic effect of ipomoea batatas in normal and alloxan.

Diabetes is a metabolic disorder due to the defect in insulin secretion or function. To avoid late complications of diabetes and related costs, primary prevention and early. The extracts were also evaluated for acute oral toxicity studies and its effect on different biochemical parameters. The mechanism of alloxan and streptozotocin action in b cells. Histophysiology of the obesity diabetes syndrome in sand rats. K p v o o evaluation and optimization of effectivedose.

Amelioration of streptozotocininduced diabetic nephropathy by. After oral administration of each mesc singly or repeatedly to alloxan. In animals, it can be induced by partial pancreatectomy or by the administration of diabetogenic drugs such as alloxan, streptozotocin, ditizona and antiinsulin serum. Introduction diabetes mellitus diabetes is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is. In an acute doseresponsestudy, blood glucose was followed over 8 h in non fasted stzdiabetic spraguedawley rats. However, in absence of aggressive stimuli such as ligatures, the influence of diabetes on rat periodontal tissues is incompletely explored. Diabetic rats were administered kaysom extract orally twice daily for. We evaluated the metabolic, oxidative, and functional effects on the liver and blood vessels, both related to diabetes complications. The mechanisms of alloxan and streptozotocininduced diabetes. Amelioration of alloxan induced diabetes mellitus and oxidative stress in rats by oil of eruca sativa seeds article pdf available in annals of nutrition and metabolism 443. Anti diabetic activity of ethanolic extract of aconitum ferox. The extracts were also evaluated for acute oral toxicity. Pdf on oct 1, 2014, mohammad zoair and others published antidiabetic effect of artemisia.

In an acute doseresponsestudy, blood glucose was followed over 8 h in nonfasted stzdiabetic spraguedawley rats. Palliative effects of daonil supplemented with tryptophan on. The rats were allowed free access to feed standard pellet diet and drinking. The present study investigates the preventive effect of fasting in alloxan induced diabetic rats. Pdf amelioration of alloxan induced diabetes mellitus and. Experimental diabetes mellitus in different animal models ncbi. It is popularly known as country fig in english and atti in tamil. A single dose of alloxan 120 mgkg body weight was used to induce diabetes in rats. Anion gap toxicity in alloxan induced type 2 diabetic rats. May 24, 2014 there are a few nutritional approaches to address the increased needs of managing diabetic conditions. Thirty male albino rats were divided equally into three groups including control, diabetic and diabetic treated with kaysom extract. After the successful induction of experimental diabetes, the rats were divided into five groups each comprising a minimum of six rats. Research article alloxan induced diabetes mellitus in wistar. Eighteen adult male wistar rats weighing 180 to 230 g were randomly divided into 3 equal groups including.

Pdf antidiabetic effect of hydroalcoholic extract of carthamus. Journal of chemical and pharmaceutical research, 2016, 84. Alloxan diabetes and streptozotocin diabetes figure 1 shows a schematic diagram of the tetraphasic and triphasic blood glucose responses induced by alloxan and streptozotocin, respectively, when injected 22. The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas t. Download limit exceeded you have exceeded your daily download allowance. Management of diabetes and hyperglycemia in hospitals.